Pharmacokinetic (PK) and Toxicokinetic (TK) Bioanalysis

Pharmacokinetic (PK) and Toxicokinetic (TK) bioanalysis is a critical aspect of drug development. These studies may be exploratory in nature or more extensive and formal. Understanding the bioavailability, exposure, half-life, clearance and metabolism of a drug may be the difference between success and failure in the clinic.

PK/TK Bioanalysis at Pacific BioLabs

Pacific BioLabs’ analytical and bioanalytical laboratory contains GLP-compliant systems and qualified instrumentation, including multiple LC/MS/MS systems as well as ELISA and MSD platforms to provide sensitive, high throughput evaluation of drug concentration in a variety of biological matrices.

PBL can quickly perform bioanalytical method development and validation of sensitive, accurate and robust PK assays in a number of biological matrices. PBL’s chemists have experience working with plasma, serum, urine, CSF, and tissues, and they will optimize the extraction conditions to provide a reproducible and robust method. PBL has supported bioanalysis for many clients from exploratory research, preclinical studies to Phase I through Phase IV clinical trials.

Additionally, PBL provides in vivo dosing and sampling in multiple animal species, and can coordinate PK studies to perform all aspects including in vivo dosing and sample collection in animals, bioanalysis, and preparation of PK data using WinNonlin.

Pharmacokinetic Studies Utilizing ICP-MS

For compounds containing metals, ICP-MS may be used to perform PK bioanalysis. ICP-MS has the benefits of low detection levels (as low as 1ppb) and high specificity. Many classes of drugs contain metals – copper, iron, platinum, gold, and cobalt are just of few examples of the many metals that can be integrated into drug molecules. PK by ICP-MS may be an excellent choice to analyze these types of compounds.

Available PK and TK Bioanalytical Services

  • Bioavailability Study Support
  • Toxicokinetics
  • Pharmacokinetics
  • PK Bioanalysis by ICP-MS
  • Exploratory Pharmacokinetics
  • Metabolite Identification
  • LC/MS/MS
  • TOF MS
  • Instrumentation Details

Read More About Pharmacokinetics and Toxicokinetics Bioanalysis Testing

PBL Learning Center – Stages of Drug Development

PBL Learning Center – Preclinical Tests Timeline

PBL’s Preclinical Toxicology Booklet
Download the free booklet

Pacific BioLabs